Too Much of a Good Thing free essay sample

To persuade my audience to be cautious in using medicines and supplements that are usually considered beneficial. Central idea:Medicines and supplements that can be beneficial are sometimes harmful if ingested in large amounts. Introduction 1. Attention-getter There is an old saying that â€Å"Too much a good thing is wonderful. † Is it always true? A young woman went out on her sailboat one Friday afternoon. She suffered a back injury, causing terrible back pain. For pain relief, she took a painkiller. For the next three days, she ingested the pills at more than twice the recommended dosage. On Tuesday, four days after she started the pills, she died en route to the hospital from liver damage. 2. Credibility Since I heard about the story, I have done some research in this area. 3. Preview of main points Today I’m going to talk about the problem of taking excessive amounts of drugs and then discuss the possible solutions. We will write a custom essay sample on Too Much of a Good Thing or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page (Transition: Let’s examine the problem in more detail. ) Body I. Many people don’t know that taking excessive amounts of medicines and supplements can be dangerous. A. Ambien, a sleeping pill, makes you sleepy, so will you go to sleep faster if you increase the dosage? 1. Perhaps, but you could suffer breathing problems, and even lapse into a coma and die. 2. This is the finding of Dr. Daniel F. Kripke, professor of psychiatry at University of California, San Diego. (The Dark Side of Sleeping Pills) B. Ibuprofen relieves pain, but if too much is taken, it can cause gastrointestinal bleeding after just three days. (General Practitioner) C. Dr. Bill Edwards, director of inpatient care at Children’s Hospital in Peoria, IL, relates the story of a child patient. 1. The child displayed all the signs of a brain tumor (dizziness, pressure inside the head, extreme headache, and blurry vision). 2. Tests could find no evidence of a tumor. 3. Further tests revealed an overdose of vitamin A. D. Vitamin A and other vitamins can be toxic in large amounts. (Dr. Joshua Hamilton, professor of toxicology at Dartmouth College) 1. Too much vitamin B6 can cause nerve damage to arms and legs. . Too much vitamin C can cause kidney stones. 3. Too much vitamin D can damage kidneys. (Transition: We’ve seen the problem – what is the solution? ) II. The solution is to be cautious and well-informed. A. Collaborate with your doctor on which pills, vitamins, and supplements you should take. B. Always study labels for dosage directions and never take more than the recommended amount. C. Be aware of possible compl ications. 1. Even if you take the recommended dosage of one medicine, there can be a toxic interaction if you are taking other drugs at the same time. . Make a list of all vitamins, supplements, and pills that you use, and include the amounts you consume. 3. Ask your doctor and pharmacist to analyze the list to make sure you are safe. D. Educate yourself. 1. See health books in a library or buy them at a bookstore. 2. Subscribe to health magazines and newsletters. E. Be careful with health info on the Internet. 1. You can trust reputable sites, such as the health sections of ABC News, MSNBC, and CBS. 2. But be cautious when search for health information using a search engine like Google. Dr. Kathis Kemper, Holistic Pediatrician) 3. Going back to Dr. Edwards and the child who overdosed on vitamin A, do you know why the child consumed megadosage? 4. The parents had been persuaded by some Websites that vitamin A is a cure for hyperactive children who can’t concentrate in school. 5. A Web search will turn up hundreds of sites that tout the healing powers of vitamin A. 6. These sites are devoted to selling supplements, so you can’t trust them to be objective. (Transition: Let’s summarize. ) Conclusion I. Summary A. Substances that can be good for you are sometimes harmful if ingested in large amounts. B. Collaborate with your doctor and pharmacist. C. Always stay within the recommended dosage. D. Stay well-informed by consulting books, magazines, and reliable websites. II. Closing remarks We know we can’t always accept the old saying, â€Å"Too much of a good thing is wonderful. † Better advice is another saying, â€Å"Too much of a good thing can be awful.

Amelia Earhart Biography paper Essay Example

Amelia Earhart Biography paper Essay Example Amelia Earhart Biography paper Paper Amelia Earhart Biography paper Paper Contemporary World Issues Biography Paper Boaz 3B By: Jerome Bircumshaw Even to this day some people believe women are not capable of achieving what the male can do. However one women in 1928 changed the image of the face of women forever. Soon to be an American aviator, Amelia Earhart was born on July 24, 1897, in Atchison, Kansas. She was the daughter of a successful railroad attorney. Because of her fathers occupation, Amelia spent her childhood growing up in many different towns. Her fascination for adventure and thrill seeking started off at a young age where Amelia and her big sister Muriel decided one day that they wanted to make a plane. There was a lack in material, so they decided to make a rollercoaster instead. Even though neither one of the girls knew how to make a roller coaster, they got some wood from an old wooden fence they tore down. First, they made the car by placing the bottoms of roller skates under a big piece of wood and the rest of the wood was used to make a slide that went from the top of a woodshed to the ground. With Amelia and her bravery, she went first and rolled quickly down the unstable slide. The car hit the ground and Amelia bounced into the air and turned into a somersault, luckily escaping injury. Years after the family moved to Des Moines, Iowa where they attended a state fair. That is when Amelia got to see her first airplane which did not impress Amelia. The airplane was made of wood and wires and reminded Amelia of a big orange crate. Because of this, she thought she would never own an airplane. Even though she was young at the time Amelia knew she wanted to do something fun in the future. One night in 1910 Amelias father took both of the girls out to see Halleys comet which passes by once every 76 years. She was really impressed by the sight and pointed out one specific star and asked if it had a name. That is Vega, her father told her. It is one of the most beautiful stars of all. Amelia shut her eyes and wish on Vega that she could do exciting things when she grew up. This wish certainly came true. The following years were good ones for Amelia, as she learned how to swim and ride horses. After she finished her high school education, she attended a school in Toronto, Canada where she visited her sister and took a course in the Red Cross First Aid. She thought being a nurse was going to be her occupation growing up as she oved helping the wounded soldiers and everyone loved her help. Years after however, she left and furthered her education as a premedical student at the Columbia University in New York. It was going well for Amelia, but her parents insisted she should move back to California with them. Shortly after, Amelia was living in California with her parents when she read in a newspaper that there was an air meet near Los Angeles. Amelia went to the air meet, with her father and they watched the planes do stunts and daredevil tricks. That was the beginning of Amelias aviation adventure. She decided she wanted to fly, ut her parents could not afford lessons for her, so Amelia got a Job to cover the expenses. Her teacher was a women, and one of the only women in the world who knew how to fly. This gave Amelia more hope that one day she would be able to fly by herself. One day she finally got to fly solo as her instructor watched. She was not the best pilot and had a rough landing, but she could say she flew an airplane. Amelias mom was proud of her and helped her to buy her own small airplane. Amelia soon became a good pilot and was reminded by men and women constantly how good her aviation skills were. Planes did not fly very high back in the early 1900s but that never stopped Amelia from setting a womens record for high flying. She flew 14,000 feet in the air, almost three miles high. With the knowledge we know now of Amelias great achievements, it is surprising to think that she had a hard time deciding on what she wanted to do. Of course she wanted to fly, but she also wanted to do some useful work. It was at Denison House in Boston where she found a social center. This is where she taught the children how to play games. She looked after them while their mothers were working, it was like a aycare. If Amelia was not taking care of the kids, she was flying. All the children were proud of her and looked up to her. In 1927, Amelia read the newspaper and learned that Charles A. Lindbergh had flown an airplane from New York to Paris. It was a major accomplishment because flying airplanes across the Atlantic was not only a hard task to accomplish but no one had ever successfully made the Journey until then. Lindbergh was the first man who accomplished the flight in history. Several women had tried to make the Journey, but none had made it. Three young women lost their lives trying. It was in Boston Massachusetts where Amelia received a call to be the first female passenger on a transatlantic flight, in 1928. Amelia asked to be a pilot, but she did not know how to use instruments which were a new invention in planes to help them from getting lost. She soon after promised herself that she would learn how to use aviation instruments. The weeks following, Amelia was sent to New York where she met her future husband and book publisher George Putnam. He was the manager of the ocean flight, and they quickly realized they had a handful of similar interests. Amelia got er first glance at the plane named Friendship that was chosen for the trip and she was pleased to say the least. The Friendship had three motors, and instead of wheels it had pontoons which meant it could float, but taking off in water was no easy task since wind was the main component to take off. The friendship had gold wings which Amelia thought was beautiful but she was informed that the gold was not for looks but instead it make the aircraft easier to spot in case the pilot had to go down in the ocean, so the plane would be spotted. One early morning in 1928, Amelia thought the weather seemed right, so the pair umped in the plane, started the engine, and sped off across the water. The first destination was Trepassy Harbor, in Newfoundland, off the coast of Canada so the airplane could be refueled before the long Journey. After they refueled and planned to head to Europe, the weather became extremely bad with thick fog and rain. Days went by, and the weather seemed to keep up. Amelia started losing hope, and then she heard the news about another young women who had flown from New York to Newfoundland. She and her pilot were staying in a town nearby. Her name was Mabel Boll, and her plane was named the Columbia. Both of the women agreed that the trip was not a race, but secretly both women wanted to be the first to complete the transatlantic Journey. Back in the United States, the newspapers called it a race. Headlines read Rival Women Flyers Still Held by Bad Weather, and Columbia ready for take off, then in big print Friendship Takes Off. On June 17, 1928, Mabel said the weather was too bad to take off, and Amelia would be the first to reach Europe. Quickly into their flight, Amelia and her pilot rode into heavy fog and were hoping to reach the coast of England before they ran out of gas. After several of hours, there was little gasoline left, but the fog life savingly lifted, and a boat was seen in the distance. However, the radio was not working properly and after several attempts to contact the boat, they simply flew on hoping to find land. Shortly after, fishing boats were seen in the distance which meant there must be land nearby but the direction was not known, so they flew forward, hoping to find something, and luckily, they spotted land in the distance and Stultz brought the plane down in the Burry Port, on the coast of Wales. Amelia was a heroine. As the first women to fly across the Atlantic, she was treated as national idol and hero. She had a positive impact on society giving hope to children and adults of both genders proving that women could do anything a man could do, or even better because her flight beat Lindbergh in the total time it took of twenty hours and forty minutes. When the crew returned to America Amelia along with the help of George Putnam published a book call ed 20 Hrs. 40 Min. While in America, Amelia flew across the country and became a better pilot than she had ever been before in her life and learned how to fly safely with instruments. She changed the female view of flying positively and became a role model to people all ver the globe. Around this time Amelia purchased her own airplane and named it Vega. She was set out to fly the transatlantic solo and be the first women to do so. On May 20, 1932, the trip to Europe alone began. Although she did not have an easy flight with ice forming on the wings and fire leaking out of the exhausts, she managed to reach Europe in a historical fifteen hours and eighteen minutes. Amelia was invited to many parties. One of which included a dance with the soon to be King of England. After their marriage George and Amelia were invited to have dinner with he President Hoover and his wife at the White House. Amelia proved that women had as much courage as men and was soon the most famous woman alive. She took the President and his wife on a short ride in a plane above Washington while wearing a evening gown and slippers. Time went by and Amelia became a teacher at Purdue University in Indiana when she decided she really wanted to make history. Amelia told George, she wanted to fly the globe, It wasnt an impossible task, but she wanted to fly around the equator which was the hardest and longest way to fly. Amelia did have a downfall and it was not knowing when to quit. With the help of George she set off on the flight from California one morning in March of 1937. She reached Hawaii in less than sixteen hours but spun into a ground loop and crashed the plane which cost eighty-thousand dollars. The plane was shipped back in pieces and fixed, and on June 1, 1937, Amelia decided to try the flight again but this time she sat off the other direction. She flew over many countries such as Africa, India and New Guinea. It was when she was supposed to stop on a small island call Howland Island that people started worrying since Amelia never reached the Island or her final destination. July 2, 1937, would be a day remembered forever, because that is the day Amelia set off from New Guinea to Howland and was never seen again. Many reports claimed she was captured or stranded in the ocean or on an uninhabited island somewhere. But the truth, however, was never discovered. I believe Amelia was one of the greatest feminist role models by changing the face of women across the globe. She was nothing short of impressive, and I would recommend this book to anyone of any age or gender because Amelia had a life that is a real eye opener and proves the there is no dream that can not be accomplished.

IT in Small Business Accounting Assignment Example | Topics and Well Written Essays - 1250 words

IT in Small Business Accounting - Assignment Example Both sides of the Balance Sheet increase by $5000. Journal entry that would affect the Income Statement would be: DR CR Retained Earnings $2000 Wages Expense $2000 Assumption: Retained Earnings decreases with the debiting and Wages Expense account decrease while being posted to the expenses in the Income Statement. Assignment 2 The primary objectives of accounting are to fairly present the financial information in the financial statements with necessary disclosures in accordance with Generally Accepted Accounting Principles (GAAP) so that users of the financial statements can use them to make informative decisions. This fulfills one of the main objectives which is to give assurance to the public about financial statements. The main objective of the firm producing financial statements is to monitor business performance throughout the year and possibly compare with past results. When comparative financial statements are compiled, a better understanding of the level of consistency can b e obtained. A part of this objective of accounting is to judge the performance of management and employees. Why isn't the company doing well when Sales have gone up? Are employees being careless with materials? Using this financial information the company can analyze the data to find out why the budgeted amounts for the operations budget and the actual data differ. In doing this, management will be able to answer questions about employee performance and it's own performance. Another objective is to record all expenses and revenues in the correct period. This is important since in order to find the financial position we must know when to post revenues and expense to the income...This fulfills one of the main objectives which is to give assurance to the public about financial statements. The main objective of the firm producing financial statements is to monitor business performance throughout the year and possibly compare with past results. When comparative financial statements are c ompiled, a better understanding of the level of consistency can be obtained. A part of this objective of accounting is to judge the performance of management and employees. Why isn't the company doing well when Sales have gone up? Are employees being careless with materials? Using this financial information the company can analyze the data to find out why the budgeted amounts for the operations budget and the actual data differ. In doing this, management will be able to answer questions about employee performance and it's own performance. Another objective is to record all expenses and revenues in the correct period. This is important since in order to find the financial position we must know when to post revenues and expense to the income statement. We also need this information to prepare tax records. Another objective is to prepare for the future of the company. Management needs to know which parts of the company are functioning inefficiently or efficiently. Certain departments m ay be functioning inefficiently and its important to know why and what can be done to prevent waste or inefficiency.

The Importance of Identity Essay Example | Topics and Well Written Essays - 250 words

The Importance of Identity - Essay Example In essence, it is argued that although ones identity is associated with good things, there is also a bad side of it. For example, some people may fear being identified with certain race or ethnicity with a perception or a belief that other races or ethnic groups are better than others. In fact, people of a certain race may be discriminated against by people of a different race especially where racism is prominent. Identity is also argued to be ones beliefs and personality. These traits constitute what people are and what they stand for. For example, in leadership, the belief of integrity in leadership may portray a picture of what one stands for, and this is what other people identify a leader with. Another example is that, if one believes in success, it is apparent that such a person would thoroughly prepare for an interview, and because of confidence and the thorough preparation, the interviewer finds a distinct personality in the interviewee, something that is factored into when recruiting people. Talent is also another form of identity, which people are identified with. It is what one is best known for that makes one distinct from others. Most of the things that happen to people are as a result of their identity. Although there is natural and constructed identity, in most cases, constructed identity occupies the biggest part of people’s lives. All in all, identity is vital in people’s

Modern variations of the Panopticon Essay Example | Topics and Well Written Essays - 1250 words

Modern variations of the Panopticon - Essay Example Bentham’s idea is that a panopticon, where the observed internalizes the presence of an unseen observer, enforces those rules via a psychological self-policing on the part of the observed. The panopticon prison, where prisoners are always within view of an observer hidden in a tower that sees all, is a very good representation of Bentham’s ideal panopticon. It is an examination of the ideas on the panopticon as it is applied in some paired relationships, exploring how checks and balances come into play in them, so that the two sides in effect are forced to play according to the rules. In effect, in this dyad relationship, the panopticon becomes a two-way mechanism, with implications that are particular to the parties in the pairing. This paper demonstrates this via a discussion of the Internet as a reciprocal modern panopticon. The internet fosters an arena where the observed follows the rules imposed on them by the law and by the authorities, and where the authorities, in their turn as ordinary users, are likewise compelled to follow the rules, and to make sure that the rules do not go too far in infringing on their personal rights under the law (Foucault 228). This first part of the essay talks about the writer's understanding of Foucault's Panopticon as a disciplinary power mechanism. The heart of the panopticon is the internalization of a power mechanism on the part of the observed, in a system designed in such a way that the observed knows that he is perennially being watched, and where the observer is forever hidden from view from the observed. This can be a paired process with both parties being observer and observed for each other. That is, the panopticon also a situation where two sides play mutual roles at the same time. In this sense it is reciprocal system that enforces the rules of the game via its very mechanism. The means of enforcement is the observed internalizing the rules, and acting in such a way as to enforce the rules, and to make the system self-perpetuating and stable. In a two-way system both have to play the role of the observed, and both internalize the rules (Foucault 228). In other words, the panopticon as a disciplinary power mechanism instills in the both parties the very rules of the game, and makes it in the best interest of both, in a way, to follow the rules without being told. What affects one affects the other in equal measure. The mechanism has within it the power to enforce. The knowledge that one is being watched at all times forces the observed to act in ways that do not violate the rules, or else face the consequences of the violation. It is self-perpetuating and becomes more effective the more it is internalized too. This is because both parties, as the observed, by internalizing the rules and the idea that he is being perpetually watched, go into themselves and look into all areas of their lives: thoughts, behavior - and seek compliance with the rules in all of those dimensions of his life. Both censor each other and are forced to follow the law as the observed, and as the observers enforcing the law (Foucault 226-228). In pairs where observation is reciprocal, the two parties balance each other's

Hplc Analysis Of Aloe Vera Tablets Biology Essay

Hplc Analysis Of Aloe Vera Tablets Biology Essay The project work was aimed to achieve the quantitative determination of aloin and aloe emodin in the form of tablets by employing HPLC. The method used was reverse phase high performance liquid chromatography. Calibration curve method was used for the quantification of aloin and aloe emodin. The mobile phase was the mixture of acetonitrile and deionised water in the ratio of 60:40 respectively. The mobile phase was pumped at 1.5 ml/minute and the analyte was quantified at the wavelength of 220 and 296nm. The column used for separation was kromasil 5C18. Reverse phase Isocratic run of standard aloin and standard aloe emodin was done and the peaks obtained from their analysis were used to compare the test sample peaks. Aloe vera colax tablets manufactured by Aloe pura laboratories were used as the test sample tablets which were extracted with water, methanol, acetonitrile, methanol-water and acetonitrile-water. After extraction they were subjected for isocratic run in HPLC instrument a nd the data obtained were compared with that of the standard. CHAPTER 1 INTRODUCTION 1.1 Introduction to Aloe Vera Aloes is the dried juice of the leaves of Aloe barbadensis Miller, known as Curacao aloes, or of Aloe perryi Baker known as Socotrine aloes, or of Aloe ferox Miller and hybrids of the species of Aloe africana Miller and Aloe spicata Baker, known as Cape aloes belonging to the family Liliaceae. [2,3] The synonym of aloes is Aalwee, Aalwyn, Kumari, Star cactus, Aroe, Acibar, Babosa, etc. [1] Aloes is indigeneous to eastern and southern Africa and grown in Cape colony, Zanzibar and islands of Socotra. It is also cultivated in Caribbean islands, Europe and many parts of India, including North West Himalayan region. [2] All the varieties of aloe are the major sources of anthraquinone glycosides. The principal active composition of aloe is aloin, which is a mixture of glucosides, among which barbaloin is the chief constituent. It is chemically aloe-emodin anthrone C-10 glucoside and is water-soluble. [2] Barbaloin is a C- glycoside and it is not hydrolysed by heating with dilute acids or alkalies. Ferric chloride decomposes barbaloin by oxidative hydrolysis into aloe-emodin-anthrone, little aloe-emodin and glucose. [2] Along with barbaloin, aloes also contains isobarbaloin, b-barbaloin, aloe-emodin and resins. The drug also contains aloetic acid, homonataloin, aloesone, chrysophanic acid, chrysamminic acid, galactouronic acid, choline, choline salicylate, saponins, mucopolysaccharides, glucosamines, hexuronic acid, coniferyl alcohol, etc. [2] The amount of barbaloin in different commercial varieties varies to a large extent. Curacao aloes contain about 22 percent of barbaloin. Indian variety, generally Aloe vera contain very less quantity (3.5 to 4 percent). Curacao aloes contains two and half times quantity of aloe-emodin , compared to Cape-aloe-emodin. [2] The resin of aloe principally contains Aloesin. It is a type of C- glucosyl chromome. Aloesin is also responsible for purgative action of aloes. [2] Fig. 1 Fig. 2 Aloin [5] Aloe emodin [6] 1.2 Uses of Aloe Vera: Aloes is used as purgative. Its effect is mainly on colon. It has a stronger purgative action in the series of all crude drugs with anthracene glycosidal content. To counter effect the gripping action, it is given along with carminatives. [2] It facilitates the healing of any kind of skin wound, burn, or scald even speeding recovery time after surgery. [4] It is applied topically in acne, sunburn, frostbite (it appears to prevent decreased blood flow), shingles, screening out x-ray radiation, psoriasis, preventing scarring, rosacea, warts, wrinkles from aging, and eczema. [2, 4] It also seems to help prevent opportunistic infections in cases of HIV and AIDS due to its immune system stimulant properties. [4] It appears to be of help in cancer patients (including lung cancer) by cativating white blood cells and promoting growth of non- cancerous cells. [4] Aloe also appears to work on heartburn, arthritis, and rheumatism pain and asthma. [2, 4] It also lowers the blood sugar levels in diabetics. [2, 4] Other situations in which it appears to work when taken internally inclue congestion, internal worms, indigestion, stomach ulcers, colitis, hemorrhoids, liver problems such as cirrhosis and hepatitis, kidney infections, urinary tract infections, prostate problems, and as a general detoxifier. [2, 4] CHAPTER 2 HPLC 2.1 HPLC: Introduction and Instrumentation The technique of high performance liquid chromatography is so called because of its improved performance when compared to classical column chromatography. It is also called as high-pressure liquid chromatography since pressure is used when compared to classical column chromatography. Instead of a solvent being allowed to drip through a column under gravity, it is forced through under high pressure of up to 400 atmospheres. For the separation, identification and quantification of compounds, this method is frequently used in biochemistry and analytical chemistry. [11, 12] The development of HPLC from classical column chromatography can be attributed to the development of smaller particle sizes. Smaller particle size is important since they offer more surface area over the conventional larger sizes. [7] 1960s 40 to 60m 1970s 10 to 20m 1980s 5 to 10m 1990s 1 to 3m A porous particle of 5m offers a surface area of 100-860 sq.metres/gram with an average of 400 sq.metres/gram. These offer very high plate counts upto 100,000/metre. Table 1: Comparison of classical column chromatography with HPLC [7] Parameter Classical column chromatography HPLC Stationary phase particle size Large 60-200m Small 3-20m Column size Length x int. diameter Large 0.5-5m x 0.5-5cm i.d. Small 5-50cm x 1-10mm i.d. Column material Glass Mostly metal Column packing pressure Slurry packed at low pressure often gravity Slurry packed at high pressure >5000 psi Operating pressure Low ( High (500 3000 psi) Flow rates Low to very low Medium to high (Often >3ml/min) Sample load Low to medium (g/mg) Low to very low (mg) Parameter Classical column chromatography HPLC Cost Low High Detector flow cell volume Large 300 to 1000ml Low 2 to 10ml Column efficiency i.e. Resolving power (Low) Theoretical plates per meter (High) often >100,000 Plates per meter Types of stationary phases available Limited range Wide range Scale of operation Preparative scale Analytical and preparative scale 2.2 Types of HPLC techniques [7, 9, 10, 11, 12] Based on Modes of Chromatography There are two modes viz. Normal phase mode and Reverse phase mode. These modes are based on the polarity of stationary phase and mobile phase. Before explaining the modes, it is important to know the interactions, which occur between solute, stationary and mobile phase. Polar Polar interaction or affinity is more Nonpolar Nonpolar interaction or affinity is more Polar Nonpolar interaction or affinity is less Normal phase mode: In normal phase mode, the stationary phase (eg. Silica gel) is polar in nature and the mobile phase is non-polar. In this technique, non-polar compounds travel faster and are eluted first. This is because of less affinity between solute and stationary phase. Polar compounds are retained for longer time in the column because of more affinity towards stationary phase and take more time to be eluted from the column. This is not advantageous in pharmaceutical applications since most of the drug molecules are polar in nature and takes longer time to be eluted and detected. Hence this technique is not widely used in pharmacy. Reverse phase mode: In reverse phase technique, a non-polar stationary phase is used. The mobile phase is polar in nature. Hence polar components get eluted first and non-polar compounds are retained for a longer time. Since most of the drugs and pharmaceuticals are polar in nature, they are not retained for a longer time and eluted faster, which is advantageous. Different columns used are ODS (Octadecyl silane) or C18, C8, C4, etc. Common reverse phase solvents are methanol, acetonitrile, tetrahydrofuran and water. Based on principle of separation Adsorption chromatography Ion exchange chromatography Ion pair chromatography Size exclusion or Gel permeation chromatography Affinity chromatography Chiral phase chromatography Each of the above technique is described in brief as follows: Adsorption chromatography: The principle of separation is adsorption. Separation of components takes place because of the difference in affinity of compounds towards stationary phase. This principle is seen in normal phase as well as reverse phase mode, where adsorption takes place. Ion exchange chromatography: The principle of separation is ion exchange, which is reversible exchange of functional groups. In ion exchange chromatography, an ion exchange resin is used to separate a mixture of similar charged ions. For cations, a cation exchange resin is used. For anions, an anion exchange resin is used. Ion pair chromatography: In ion pair chromatography, a reverse phase column is converted temporarily into ion exchange column by using ion pairing agents like pentane or hexane or heptane or octane sulphonic acid sodium salt, trtramethyl or tetraethyl ammonium hydroxide, etc. Size exclusion or gel permeation chromatography: In this type of chromatography, a mixture of components with different molecular sizes is separated by using gels. The gel used acts as molecular sieve and hence a mixture of substances with different molecular sizes is separated. Soft gels like agarose , dextran or polyacrylamide are used. Semi rigid gels like polystyrene, alkyl dextran in non-aqueous medium are also used. The mechanism of separation is by steric and diffusion effects. Affinity chromatography: Affinity chromatography uses the affinity of the sample with specific stationary phases. This technique is mostly used in the field of Biotechnology, Microbiology, Biochemistry, etc. Chiral phase chromatography: Separation of optical isomers can be done by using chiral stationary phases. Different principles operate for different types of stationary phases and for different samples. The stationary phases used for this type of chromatography are mostly chemically bonded silica gel. Based on elution technique 1. Isocratic separation: In this technique, the same mobile phase combination is used throughout the process of separation. The same polarity or elution strength is maintained throughout the process. In this technique, the peak width increases with retention time linearly according to the equation for N, the number of theoretical plates. Gradient separation: In this technique, a mobile phase combination of lower polarity or elution strength is used followed by gradually increasing the polarity or elution strength. One example is a gradient starting at 10% acetonitrile and ending at 90% acetonitrile after 25 minutes. The two components of the mobile phase are termed as A and B. Where A is the weak solvent and B is the strong solvent. Weak solvent allows the solute to elute slowly while strong solvent rapidly elutes the solutes from the column. A is usually water where as B is an organic solvent which is miscible with water such as acetonitrile, methanol, THF or isopropanol. Based on scale of operation 1. Analytical HPLC: Where only analysis of the samples are done. Recovery of the samples for reusing is normally not done, since the sample used is low. Eg. mg quantities. 2. Preparative HPLC: Where the individual fractions of pure compounds can be collected using fraction collector. The collected samples are reused eg. Separation of few grams of mixtures by HPLC. Based on type on analysis 1. Qualitative analysis: Which is used to identify the compound, detect the presence of impurities, to find out the number of components, etc. This is done by using retention time values. 2. Quantitative analysis: Which is done to determine the quantity of the individual or several components in a mixture. This is done by comparing the peak area of the standard and sample. 2.3 Principle of separation in HPLC: [7, 9] The principle of separation in normal phase and reverse phase mode is adsorption. When a mixture of components is introduced in to a HPLC column, they travel according to their relative affinities towards the stationary phase. The component, which has more affinity towards the adsorbant, travels slower. The component, which has less affinity towards the stationary phase, travels faster. Since no two components have the same affinity towards the stationary phase, the components are separated. 2.4 Instrumental Requirements [7, 9, 10, 12] Pumps solvent delivery system Mixing unit, gradient controller and solvent degassing Injector Manual or auto injectors Guard columns Detectors Recorders and integrators Fig. 3 The schematic diagram of HPLC [13] 1. Pump Solvent delivery system The solvents or mobile phases used must be passed through the column at high pressure at about 1000 to 3000 psi. This is because as the particle size of stationary phase is few m (5 10m), the resistance to the flow of solvent is high. Hence such high pressure is recommended. There are different types of pumps available. They are mechanical pumps and pneumatic pumps. A mechanical pump operates with constant flow rate and uses a sapphire piston. This type of pump is used in analytical scale. Pneumatic pumps operate with constant pressure and use highly compressed gas. The solvents used must be of high purity, preferably HPLC grade and filtered through 0.45m filter. Check valves: These are present to control the flow rate of solvent and back pressure. Pulse dampners: These are used to dampen the pulses observed from the wavy baseline caused by the pumps. 2. Mixing unit, gradient controller and solvent degassing Mixing unit is used to mix solvents in different proportions and pass through the column. There are two types of mixing units. They are low pressure mixing chamber, which uses helium for degassing solvents. High pressure mixing chamber does not require helium for degassing solvents. Mixing of solvents is done either with a static mixer, which is packed with beads, or dynamic mixer, which uses magnetic stirrer and operates under high pressure. Gradient controller In an isocratic separation, mobile phase is prepared by using pure solvent or mixture of solvents, i.e. solvent of same eluting power or polarity is used. But in gradient elution technique, the polarity of the solvent is gradually increased and hence the solvent composition has to be changed. Hence a gradient controller is used when two or more solvent pumps are used for such separations. Solvent degassing Several gases are soluble in organic solvents. When solvents are pumped under high pressure, gas bubbles are formed which will interfere with the separation process, steady baseline and the shape of the peak. Hence degassing of the solvent is important. This can be done by using any one of the following technique. Vacuum filtration which can remove all air bubbles. But it is not always reliable and complete. Helium purging i.e. by passing helium through the solvent. This is very effective but helium is expensive. Ultrasonication by using ultrasonicator, which converts ultra high frequency to mechanical vibrations. This causes the removal of air bubbles. 3. Injector Manual or auto injectors Several devices are available either for manual or auto injection of the sample. Different devices are: Septum injectors for injecting the sample through a rubber septum. This is not common, since the septum has to withstand high pressure. Stop flow (on line) in which the flow of mobile phase is stopped for a while and the sample is injected through a valve device. Rheodyne injector (Loop valve type) It is the most popular injector. This has a fixed volume loop like 20ml or 50ml or more. Injector has two modes, i.e. load position when the sample is loaded in the loop and inject mode, when the sample is injected. 4. Guard column Guard column has very small quantity of adsorbent and improves the life of the analytical column. It also acts as a prefilter to remove particulate matter, if any, and other material. Guard column has the same material as that of analytical column. Guard column does not contribute to any separation. 5. Analytical columns Analytical column is the most important part of HPLC technique, which decides the efficiency of separation. There are several stationary phases available depending upon the technique or mode of separation used. Column material: The columns are made up of stainless steel, glass, polyethylene and PEEK (Poly ether ether ketone). Most widely used are stainless steel, which can withstand high pressure. Latest ones are PEEK columns. Column length: Varies from 5cm to 30cm Column diameter: Ranges from 2mm to 50mm Particle size: From 1m to 20m Particle nature: Spherical, uniform sized, porous materials are used. Surface area: 1 gram of stationary phase provides surface area ranging from 100 860 sq.m with an average of 400 sq.m. Functional group: the functional group present in stationary phase depends on the type of chromatographic separation. In normal phase mode it contains the silanol groups (hydroxy group). In reverse phase mode it contains the following groups: C18 Octa Decyl Silane (ODS) column C8 Octyl column C4 Butyl column CN Nitrile column NH2 Amino column For other modes of chromatography, ion exchange columns, gel columns, chiral columns, affinity chromatographic columns, etc. are available. 6. Detectors [7,9,10] Detectors used depend upon the property of the compounds to be separated. Different detectors available are UV detector: This detector is based upon the light absorption characteristics of the sample. Two types of this detector are available. One is the fixed wavelength detector, which operates at 254nm where most drug compounds absorb. The other is the variable wavelength detector, which can be operated from 190nm to 600nm. Refractive index detector: This is a non-specific or universal detector. This is not much used for analytical applications because of low sensitivity and specificity. Flourimetric detector: This detector is based on the fluorescent radiation emitted by some class of compounds. The exitation wavelength and emission wavelength can be selected for each compound. This detector has more specificity and sensitivity. The disadvantage is that some compounds are not fluorescent. Conductivity detector: Based upon electrical conductivity, the response is recorded. This detector is used when the sample has conducting ions like anions and cations. Amperometric detector: This detector is based on the reduction or oxidation of the compounds when a potential is applied. The diffusion current recorded is proportional to the concentration of the compound eluted. This is applicable when compounds have functional groups, which can be either oxidised or reduced. This is a highly sensitive detector. Photodiode array detector (PDA detector): This is a recent one, which is similar to UV detector, which operates from 190 600nm. Radiations of all wavelengths fall on the detector simultaneously. The resulting spectrum is a 3-D or three-dimensional plot of Response Vs Time Vs Wavelength. The advantage is that the wavelength need not be selected, but the detector detects the responses of all the compounds. 7. Recorders and integrators Recorders: They are used to record the responses obtained from detectors after amplification, if necessary. They record the baseline and all the peaks obtained, with respect to time. Retention time for all the peaks can be found out from such recordings, but the area of individual peaks cannot be known. Integrators: Integrators are improved version of recorders with some data processing capabilities. They can record the individual peaks with retention time, height, and width of peaks, peak area, percentage of area, etc. Integrators provide more information on peaks than recorders. Now a days computers and printers are used for recording and processing the obtained data and for controlling several operations. 2.5 Parameters used in HPLC [7, 9, 10] Retention time (Rt): Retention time is the difference in the time between the point of injection and appearance of peak maxima. Retention time is the time required for 50% of a component to be eluted from a column. Retention time is measured in minutes or seconds. Retention time is also proportional to the distance moved on a chart paper, which can be measured in cm or mm. Retention volume (Vr): Retention volume is the volume of mobile phase required to elute 50% of the component from the column. It is the product of retention time and flow rate. Retention volume = Retention time x flow rate Separation factor (S): Separation factor is the ratio of partition co-efficient of the two components to be separated. It can be expressed and determined by using the following equation: S = Kb/ Ka = Ka/ Kb = (tb t0)/ (ta t0) Where, t0 = Retention time of unretained substance Kb, Ka= Partition coefficients of b and a tb, ta = Retention time of substance b and a S = depends on liquid phase, column temperature If there is more difference in partition coefficient between two compounds, the peaks are far apart and the separation factor is more. If the partition coefficients of two compounds are similar, then the peaks are closer and the separation factor is less. Resolution: Resolution is a measure of the extent of separation of two components and the baseline separation achieved. It can be determined by using the following formula: Rs = 2 (Rt1 Rt2)/ (W1 +W2) Theoretical plate (Plate theory): A theoretical plate is an imaginary or hypothetical unit of a column where distribution of solute between stationary phase and mobile phase has attained equilibrium. A theoretical plate can also be called as a functional unit of the column. HETP Height Equivalent to a Theoritical Plate [18, 7] A theoretical plate can be of any height, which decides the efficiency of separation. If HETP is less, the column is more efficient. If HETP is more, the column is less efficient. HETP can be calculated by using the following formula: HETP = length of the column/ number of theoretical plates HETP is given by Van Deemter equation HETP = A + (B/u ) + Cu Where, A = Eddy diffusion term or multiple path diffusion which arises due to packing of the column. This is unaffected by mobile phase velocity or flow rate. This can be minimised by uniformity in packing. B = Longitudinal diffusion term or molecular diffusion which depends on flow rate. C = Effect of mass transfer which depends on flow rate. u = Flow rate or velocity of the mobile phase. A column is efficient only when HETP is minimum. Hence an ideal flow rate corresponding to the minimum value of HETP is used. Efficiency (No. of theoretical plates): The number of theoretical plates expresses efficiency of a column. It can be determined by using the formula: n = 16 Rt ²/w ² Where, n = no. of theoretical plates Rt = retention time w = peak width at base Rt and w are measured in common units (mm or cm or minutes or seconds) and are proportional to the distances marked on chart paper. If the number of theoretical plates is high, the column is said to be highly efficient. If the number of theoretical plates is low, the column is said to be less efficient. For gas chromatographic columns, a value of 600/ metre is sufficient. But in HPLC, high values like 40,000 to 70,000/ metre are recommended. Asymmetry factor: A chromatographic peak should be symmetrical about its centre and said to follow Gaussian distribution. In such cases, the peak will be like an isosceles triangle. But in practice, due to some factors, the peak is not symmetrical and shows tailing or fronting. Fronting is due to saturation of stationary phase and can be avoided by using less quantity of sample. Tailing is due to more active adsorption sites and can be eliminated by support pre-treatment, more polar mobile phased increasing the amount of liquid phase. Asymmetry factor (0.95 to 1.05) can be calculated by using the formula: AF = b/a (b and a calculated at 5% or 10% of the peak height) 2.6 Applications of HPLC HPLC is being more widely used in several fields. Apart from its use in Pharmaceutical field, it is used in Chemical and Petrochemical industry, Environmental applications, Forensic applications, Biochemical separations, Biotechnology, Food analysis, etc. In fact there is no field where HPLC is not being used. It is a versatile and sensitive technique, which can be used in several ways. Some of them are listed below: Qualitative analysis: It is nothing but identification of compound. This is done by comparing the retention time of the sample as well as the standard. Under identical conditions, the retention time of the standard and the sample are same. If there is a deviation, then they are not the same compound. Checking the purity of the compound: By comparing the chromatogram of the standard and that of the sample, the purity of the compound can be inferred. If additional peaks are obtained, impurities are present and hence the compound is not pure. From the percentage area of the peaks obtained, the percentage purity can also be known. Presence of impurities: This can be seen by the presence of additional peaks when compared with a reference standard or reference material. The percentage of impurities may also be calculated from peak areas. Quantitative analysis: The quantity of a component can be determined by several methods like a. Direct comparison method By injecting a sample and standard separately and comparing their peak areas, the quantity of the sample can be determined. Area of the peak = peak height x width of peak at the half height A1/ A2 = a (W1/ W2) Where, A1 and A2 are peak area of sample and standard W1 and W2 are weight or concentration of sample and standard a is the response factor b. Calibration curve method: In calibration curve method, series of standards are used to determine their peak areas. A calibration curve of peak area Vs concentration of the drug is plotted. From the peak area of the unknown sample, by intrapolation, the concentration of the sample can be determined. This method has the advantage that errors, if any, are minimised. Internal standard method: In this method, a compound with similar retention characteristics is used. A known concentration of the internal standard is added to the sample solution whose concentration is not known. The chromatogram is recorded and their peak areas are determined. By using formula, the concentration of unknown solution is determined. Multicomponent analysis or Determination of mixture of drugs: Similar to the quantification of a single drug, multicomponent analysis can be done easily. The quantity of each component is determined by using any one of the above methods. Marketed formulations, which contain several drugs, can be determined quantitatively for each component. Isolation and identification of drugs or metabolites in urine, plasma, serum, etc. can be carried out. Isolation and identification of mixture of components of natural or synthetic origin. Biopharmaceutical and Pharmacokinetic studies. Stability studies. Purification of some compounds of natural or synthetic origin on preparative scale. 2.7 Limitations: [7, 10] The limitations of HPLC are that drugs have to be extracted from their formulations prior to analysis and large amounts of organic solvent waste are generated which are expensive to dispose off. CHAPTER 3 Experimental Selection 3.1 Aim of Project: The aim of this project was to carry out the quantitative determination of the active pharmaceutical ingredient aloin and aloe-emodin in the given Aloe Vera Colax tablets, manufactured by Aloe Pura laboratories and to compare the results with the given standard aloin and aloe-emodin. The technique used for analysis was reverse phase High Performance Liquid Chromatography method. The analysis was performed using standard calibration curve generated at 220 and 296nm wavelength. 3.2 Chromatographic equipment and conditions: All the chromatographic equipments and conditions, which were used to perform HPLC in a laboratory environment under simulated GLP compliance conditions, are listed below. 3.2.1 HPLC system 5 (used for isocratic elution): This system is manufactured by Agilent technologies 1200 series, whose model number is G1310A and the serial number is DE 62956545 3.2.2 Software used: The software used was Microsoft windows XP, Pentium D whose product number is G 2175 BA, revision code is B. 03. 01 and its registration number is CL1CE8DB0F 3.2.3 Column used: The column used was Kromasil 5C18 whose test number is 9203- 10344 3.2.4 Pipette used: The pipette used was Volac ultra (made in U.K.), S. No. 29186, Model: R680/ F, 0-1000 mL and Volac ultra (made in U.K.), S.No. 29185, Model: R680/ F, 500-5000 mL. 3.2.5 Analytical Balance: Mettler balance AC 88 was used to weigh the sample drug whose Biom

FIR Filter Design

The objective of this project is to use three different design methods to design a low-pass filter that meets specifications given, and then compare these three different methods through different parameters. In this project, seven filters should be designed using Matlab. And we compare them on worst case gain, largest tap weight coefficient, maximal passband and stopband error, magnitude frequency response, impulse response, group delay and zeros/poles location. Finally, use these filters to do filtering, and then compare their responses to the predicted one. Discussion of Results: > Part 1: Window Method (a) Use fir1 function to synthesize an FIR that meets specifications using a boxcar window. Worst gain = 1.8372 Largest tap weight coefficient = 0.3694 Maximal passband error = 0.1678 Maximal stopband error = 0.0795 (b) Use Hann window to synthesize an FIR that meets specifications. Worst gain = 1.4154 Largest tap weight coefficient = 0.3496 Maximal passband error = 0.0052 Maximal stopband error = 0.2385 **Filter #1 is the unwindowed design, and Filter #2 is the windowed design. From the comparison above, we can see that the unwindowed design has a more critical passband and stopband edge, but the windowed one has a smaller maximal passband error as we expected. Also, the windowed one has a larger attenuation on stopband than the unwindowed one. The group delay responses of two designs are the same. (c) Use Kaiser window to synthesize an FIR that meets specifications Worst gain = 1.6900 Largest tap weight coefficient = 0.3500 N = 21 (which is in 20 in matlab) Maximal passband error = 0.0706 Maximal stopband error = 0.0852 ** Filter #1 is the unwindowed design, and Filter #2 is the kaiser design. From the comparison above, we can see that both designs have critical passband and stopband edges, but the kaiser one has a smaller maximal passband error as we expected. Also, the kaiser one has a smaller attenuation on stopband compare with the unwindowed one. The group delay responses of two designs are different, the Kaiser one only has 20th order, so the group delay is 10, not 11 as the unwindowed one. (d)The zeros of the three windowed designs ** Filter #1 is the â€Å"boxcar† design, and Filter #2 is the Hann design, Filter #3 is the Kaiser design. From figure above, we can see that Hann design has a zero far from unit circle, which is corresponding to the slower attenuation compared to the other two designs. The zeros of â€Å"boxcar† design are similar to the Kaiser design. > Part 2: LMS Method (a) Using Matlab's firls function to meet the original design specification. Worst gain = 1.5990 Largest tap weight coefficient = 0.3477 Maximal passband error = 0.0403 Maximal stopband error = 0.1137 ** Filter #1 is the 2(a) design, and Filter #2 is the â€Å"boxcar† design. From the comparison above, we can see that the â€Å"boxcar† design has a more critical passband and stopband edge, but the LMS one has a smaller maximal passband error as we expected. Also, the LMS one has a larger attenuation on stopband than the â€Å"boxcar† one. The group delay responses of two designs are the same. (b) Using Matlab's fircls1 function to meet the original design specification. Worst gain = 1.6771 Largest tap weight coefficient = 0.3464 Maximal passband error = 0.0516 Maximal stopband error = 0.0782 ** Filter #1 is the 2(a) design, and Filter #2 is the 2(b) design. From the comparison above, we can see that the 2(b) design has a more critical passband and stopband edge, but the 2(a) one has a smaller maximal passband error. Also, the 2(a) one has a larger attenuation on stopband than the 2(b) one. The group delay responses of two designs are the same. (c)The zeros of the two LMS designs ** Filter #1 is the 2(a) design, and Filter #2 is the 2(b) design. From figure above, we can see that 2(b) design has a zero far from unit circle, which is corresponding to the slower attenuation compared to the other design. The zeros around the unit circle are similar to each other. > Part 3: Equiripple Method (a) Using Matlab's firgr function to meet the original design specification (uniform error weight) Worst gain = 1.6646 Largest tap weight coefficient = 0.3500 Maximal passband error = 0.0538 Maximal stopband error = 0.0538 ** Filter #1 is the 3(a) design, and Filter #2 is the â€Å"boxcar† design. From the comparison above, we can see that the â€Å"boxcar† design has a more critical passband and stopband edge, but the 3(a) one has a smaller maximal passband error. Also, the â€Å"boxcar† one has a larger attenuation on stopband than the 3(a) one. The group delay responses of two designs are the same. (b) Using Matlab's firpm function to meet the original design specification Worst gain = 1.6639 Largest tap weight coefficient = 0.3476 Maximal passband error = 0.0638 Maximal stopband error = 0.0594 ** Filter #1 is the 3(a) design, and Filter #2 is the 3(b) design. From the comparison above, we can see that the 3(b) design has a more critical passband and stopband edge. And the stopband error is 0.0488 (which is consistent with 0.0538*(1-20%)=0.04304), the passband error is 0.0639 (which is consistent with 0.0538/(1-20%)=0.06725). The group delay responses of two designs are the same. (c) The zeros of the two equiripple designs ** Filter #1 is the 3(a) design, and Filter #2 is the 3(b) design. From figure above, we can see that 3(a) design has a zero far from unit circle, which is corresponding to the slower attenuation compared to the other design (almost no attenuation on the figure shown ). There is only one zero stays outside the unit circle for 3(b) design, which is the minimum phase design. > Part 4: Testing (a)Table the features for the 7 designed FIRs: Features Filter #1 Filter #2 Filter #3 Filter #4 Filter #5 Filter #6 Filter #7 Maximum gain 1.8372 1.4154 1.6900 1.5990 1.6771 1.6646 1.6639 Maximum passband linear 0.1678 0.0052 0.0706 0.0403 0.0516 0.0538 0.0638 Maximum passband error(dB) -15.5052 -45.7568 -23.0266 -27.8855 -25.7472 -25.3838 -23.9007 Maximum stopband linear 0.0795 0.2385 0.0852 0.1137 0.0782 0.0538 0.0594 Maximum stopband error(dB) -21.9886 -12.4495 -21.3913 -18.8858 -22.1339 -25.3838 -24.5274 Group delay 11 11 10 11 11 11 11 Largest tap weight coefficient 0.3694 0.3496 0.3500 0.3477 0.3464 0.3500 0.3476 (b) From the figure followed, we can figure out that the group delay is 22-11=11 samples regardless of the input frequency. (c) Compare the original, mirror, and complement FIR's impulse, magnitude frequency, and group delay response **Filter #1 is the original filter, Filter #2 is the mirror filter, and Filter #3 is the complement filter. (d) Maximal output is 1.8372, which equals to the worst gain prediction of this filter. > Part 5: Run-time Architecture (a) N = 8, M=1; N = 12, M=1; N = 16, M=1; Round off error N=8 N=12 N=16 From the comparison above, we can see clearly that as the value of N increases, the round-off error decreases. Bits of precision is N-1-1=N-2 (b) Choose two 12-bit address space which has memory cycle time of 12 ns, so the maximum run-time filter speed is 1/ (12ns/cycle*16 bits) =1/ (192 ns/filter cycle) =5.21*106 filter cycles/sec > Part 6: Experimentation (a) The maximal of the output time-series is 1.1341. It is reasonable, because it is smaller than the worst case gain which is 1.8372. So this agrees with the predicted filter response. (b) The â€Å"chirp† function makes a short, high-pitched sound, and it sounds four times, which is corresponding to the 4*fs. When all the .wav files are played, we can hear obviously that the frequency of output sound is much lower than the frequency of input sound, which means that the filter did filter high-frequency components out. From the figure above, we can see the high-frequency components are gone, which agrees with the predicted filter response, a low-pass filter. Summary: Through this project, the detailed processes of designing a filter by three different methods have been understood. And we know more about all the parameters which would affect properties of the filters, and how to use different methods to design them and make best trade-off between each other.

Psychology Ch 6 Answer to Study Guide

Chapter 6: 1. From an operant conditioning perspective, it is important for parents to â€Å"catch kids being good† and praise them. In operant condition we learn based on the action and consequence. For example, parents tell their kids to clean their room. Then when they clean up their room, we give them candy or money. Another example would be when parents see their children or pets doing something good without having to tell them, in result they reward them. Children will soon do it all the time on their own. This is so difficult to do because after a while they will always expect a reward or praise after doing something good. 2.A normal fear of mines our be my fear of dogs. I consider it a normal fear because my neighbor use to always get a pit-bull and they would always get loose whenever he wasn’t at home. So we couldn’t go outside or do anything fun. For example, one day we miss school one morning because the dog was loose and my sister and I was afraid it would attack us. A fear of mines that I think is a phobia is Arachnophobia and Astraphobia. The fear of spiders and lightning. I really don't remember how I develop these fears, but every time I see a spider I run the opposite direction. When it lightning I do not go outside or in a room with lots of windows.However, I do remember how I develop my fear of dogs. When I was little my grandmother use to say if you be bad that dog is going to bit you. At this time my uncle was staying with my grandmother and he had two big dogs that was supposal harmless. 3. I agree that all this talk about the negative effects of violence on TV and in video games is an over reaction. Parents should monitor what their children are expose to. Simply, because the violence they see can lead some people to think and believe that its okay do the same thing in real life. The video games that they play only make them more curious.For example, my mom would tell us not to disobey my grandmother while she was wa y at work. So my sister and brother would wait until our grandma would fall asleep to watch what we wanted to. My mother had told us not to watch so much TV, because most of the TV shows had violence and a lot of other things she didn’t want us to be watching or hear. So my brother decided not to listen and watch and practice what he saw on tv. On day my mother caught him practicing what he saw and hear. Chapter 11 Journal 4. The most dominant part of my personality is my ego. The ego because based on Freud examples in the book and his explanation.Pushing myself to do something like the ID. Instead of, feeling guilty and tell myself not to think of it anymore. Um like the ego, always have a plan in case something goes wrong. Especially when I do something wrong. I mostly experience neurotic anxiety, according to Freud. Freud Wald says, I develop neurotic anxiety when my id gets out of control and my ego cant help it. I have no control over my id. 5. One time I was babysitting my two little cousin. I knew I wasn’t suppose to take them out and let them watch a scary movie. I figure they was already sick and it saw very cold outside and raining.In this situation I used my id and developed moral anxiety. After that they had caught pneumonias and I felt really guilty. Behaviorist would new this event as an experience and next time I would do it again. 6. The behaviorist and social learning theories is the theory of personality from this chapter that better explain my personality. I say this because their behavior is determine. Our personality structure is based on habits and expectances and our barriers to personal growth is an maladaptive habits, and unhealthy environment. Chapter 13 Journal: 1. If I was suffering from a major depression, I would consider taking an anti-depression.Because I would like to feel normal, and not so depress all the time. Plus, major depression can create suicide thoughts. Yes, if I was a diabetic or having a heart or live r problems. I would take medications for these conditions. I really don’t know about this one but probably because the others issues can cause more serious problems and we wouldn’t really know when our brains are broken. 2. Yes, we can expect that the incidence of schizophrenia to risk. I say this because according to the book, it says that one of the cause of schizophrenia environment.In environment, the problem is the victim has been expose to violence, sexual abuse, death, divorce, separation. Which mostly comes from dysfunctional families. But not everyone that are exposed to these living conditions will be schizophrenia. 3. I feel that it is a good idea to force mentally ill homeless people into an institutional setting and treat them for their own good even if they refused the treatment. Simply because they can hurt themselves and others around them. No one should want or let someone who post a harm to themselves and others around them to wondering around.

Essay about Security Wi

Essay about Security Wi Essay about Security: Wi-fi and Wireless Access Point Thesis What is my project (statistics.gov.uk/cci/nugget.asp?id=8) The UK has a very intensive Rail network system which spreads out across the whole country. It is used by millions of users. There is currently 21000 miles of track lied out across the network. According to statistics.gov.uk in the year 2010 1.32 billion people used the trains. This is statistic show the magnitude off the rail and that there is hugh potential in using is client base. According to national statistics 30.1 million adults in the UK where using internet every day, this is more then 60 percent of the adult population. In line with the amount of users now online they has also been a rise in users watching TV and Listening to the radio over the internet which in 2010 reached 17.4 million a day. Social networking has also risen in popularity with more then 65 percent of those online users using different types of social networking websites, chat rooms and blogs. What this shows is that we are living in the digital age were 70 percent of us need to be able to access information from the web. Now we now that there was 1.2 billion user of the rail network and we also now that more then half of the UK adult population use internet daily. We therefore argue the point that more then half of the rail network users use internet which means more then 600 million users of the rail network are internet users. Another statistic tells us that a recent study has shown that more then 80 percent of the adult population carry a mobile phone and 40 percent of those are wifi enabled. While on a trains user mostly access the internet via their mobile network provider, and this service is not great while on a fast moving train. User encounter loss of signal poor reception and rarely seem to have a good connection at all. The aim of my project is to provide a constant internet signal on a moving train utilising wireless connectivity. This will aloow users to connect to the internet while on the train using any wireless enabled devices such as Tablet Pc, mobile phone, laptop exe.... As wifi signal from one router is limited I will be intending to use many routers which will run along the train track. Power to them will be provided by the power terminals already existing along train track and phone-line. This will provide train customers to access internet constantly through out their journey with no loss of signal and speed. What will I use: Types of technology available for accessing the internet (http://en.wikipedia.org/wiki/Broadband_Internet_access) accessed on 16-02-2011 Mobile Broadband (explainthatstuff.com/mobilebroadband.html) There are two ways in which you can connect to a mobile broadband, if you have a smart phone which has HSPDA you can access fast mobile broadband or you can purchase a USB Dongle from most mobile network providers. Most major cities in the UK are covered by the 3G network Advantage The advantage of using mobile Broadband is that it has a larger coverage then wireless network. Where ever you can get a reasonable mobile connection you are more than likely to get a good mobile broadband connection. Disadvantage Mobile broadband has its downsides, as you are using the mobile phone provider’s network the quality of the signal you receive can vary from a good signal to a very poor signal, thus loss of connection occurs. When using mobile broadband on a train you can expect to lose connection very often as trains go under tunnels and bridges, this makes for a bad user experience. Satellite Broadband (http://computer.howstuffworks.com/question606.htm) (pcworld.com/article/17617/how_it_works_satellite_internet_access.html) High speed internet that uses a satellite dish on the receiving side similar to what satellite TV uses. The way in which internet is accessed is very similar to how Satellite television is received, a BIRD orbiting the earth beams down data to your dish. The way it works is you

The Alchemist Summary Part One Essays

The Alchemist Summary Part One Essays The Alchemist Summary Part One Essay The Alchemist Summary Part One Essay Mabel Medina July 1, 2012 English 513 Kelly Understand The Alchemist Summary In â€Å"Part One† of The Alchemist by Paulo Coelho, is so far about a boy named Santiago starting out his quest in the search of his Personal Legend. Santiago is a shepherd who likes to travel and enjoys being around his sheep. Although he travels all over, there was a certain village the shepherd boy enjoyed going to sell his sheep’s wool because he liked the merchant’s daughter. The author describes Santiago recall why he decided to become a shepherd and how his father helped him by giving him three gold coins to buy his flock of sheep. The boy was happy being a shepherd; he had his sheep, a jacket and book. One day, Santiago went to a Gypsy where he tells her about a recurrent dream he has had about finding treasure in the Egyptian pyramids. The Gypsy does not give him a lot of information about his dream, but does tell him that if he finds the treasure, to give her one-tenth. Later on that day, the boy is reading his book, when an old man came by him and tried to start a conversation. When the old man finally got the boy’s attention, he tells him he is the King of Salem, and how he can find the hidden treasure, but wants one-tenth of his sheep in return. The old man also tells the boy to not give up and to go forth and search for the treasure before it is too late and he gives up. The next day, Santiago met up with the old man and gives him one-tenth of his sheep. In return, the old man gave the boy advice that would be helpful throughout his journey, and two rocks, Urim and Thummim (one black meaning yes, and the other white, meaning no), to help him read omens better. Santiago began his journey and went to Africa. While in Africa, as the author describes, the boy feels insecure because of the language barrier, but quickly entrusts in a boy who speaks the same language as he and invites him along his journey. The two boys go into the plaza, and Santiago’s new friend is suddenly out of sight, with all of his money, and he later realizes that his â€Å"friend† has robbed him. The following day, the boy observes a candy seller, and as he is doing so, he realizes that he needs to have patience on his journey. A crystal merchant notices Santiago in the plaza and watches him. Santiago offers to clean his glass windows in exchange for food. As Santiago was working, two customers went in the shop, and the crystal merchant offers him a job, taking the customers as a good omen. The boy accepts, telling him that he will work for him until he has enough money to buy some sheep.

CSR Essay Example | Topics and Well Written Essays - 2750 words

CSR - Essay Example The recent years have witnessed mounting pressures from various stakeholder groups for corporations to incorporate sustainability into their supply chain management procedures. Sustainable or green supply chain management can be roughly defined as the management of all activities right from the purchase from suppliers to taking back the disposed product from the customers with a special focus on improving the social and environmental impacts of those activities (Business Guide, 2003). This can be contrasted with the conventional supply chain management focused only on the activities until delivery of manufactured products or services to the customers. Therefore, the environmental responsibility has drifted away from the consumer to the manufacturer and retailer (Business Guide, 2003). However, research has suggested that companies require not only the internal capacities, resources and corporate culture to achieve sustainability but also an ‘external fit’ to achieve stra tegic collaboration with their suppliers (Kanter, 1994) which presents a challenge to companies embracing this philosophy. Furthermore, the grey area surrounding the definition of ‘sustainability’ and ‘green supply chain’ means that sustainable SCM has to be discussed in terms of reverse logistics, closed loop supply chain and various other drivers. There are several drivers for a sustainable supply chain management primarily because of the related benefits to various stakeholders. These include government Regulations, Market forces, Customers, Investors and Employees. The government owns the primary responsibility to influence supply chain sustainability. Government can achieve progress on this by effective use of bans, subsidies and incentives. The government can come up with measures such as environmental labels, licenses and product design guidelines (Business Guide, pp. 42). There are already a number of regulations in place for sustainability. These i nclude U.S. Farm security and rural investment act (2002), European Union’s Restriction of Hazardous Substances (RoHS), China ROHS, E.U. Cosmetics directive, E.U. Packaging Directive, Waste Electrical and Electronic Equipment (WEEE) and REACH. In addition there are International Standards such as WRAP, FLA, ICTI CARE, ISO 14000 and ISO 26000 for addressing environmental causes (Business for Social Responsibility, 2007). As far as the market forces are concerned, the relationship between brand owners and retailers is changing. Big retailers such as Wal-Mart have a huge clout over the manufacturers and control the types of products they want to keep on their shelves. In addition, the retailers and brand owners are also under tremendous pressure from NGOs and other organizations working for environmental causes. As far as the customers are concerned, there is a long way to go before the customer becomes mature enough to buy only environment friendly products. However, the shift has already begun and the customers are willing to spend a few extra dollars to promote or support green supply chain initiatives. WholeFoods charges higher prices for its products than a retailer such as Wal-Mart but is still acceptable to customers because of the sustainable practices being followed in the manufacturing of those products. Furthermore, there are several socially

Congenital Adrenal Hyperplasia Term Paper Example | Topics and Well Written Essays - 1250 words

Congenital Adrenal Hyperplasia - Term Paper Example pag,). In humans, the gene coding for 21-hydroxylase is located at the major histocompatibility complex on chromosome 6p21.3. Partial deletions, as well as point missense and nonsense mutations, have been found to cause such chromosomal aberrations (Riepe, et al. 2563). Clinical Presentation Early diagnosis is more difficult in cases of CAH because no physical symptoms are present at birth. Thus, the presence of the condition is missed until the age of puberty is reached, when the expected physical changes are not met. As an individual with CAH ages, ambiguous genitalia, accelerated growth, and premature skeletal maturation are seen, due to excessive adrenal androgen production. In males, enlarged penises are noticed even during pre-puberty. On the other hand, such genital enlargement is seen in females as clitoromegaly. In addition, females with CAH present with oligomenorrhea, hirsutism, absence of secondary sexual characteristics, and/or fertility. Because of these features, femal es with undiagnosed CAH are nurtured as males. Among males, severe cases cause severe symptoms such as failure to thrive, recurrent vomiting, dehydration, hypotension, hyponatremia, hyperkalemia, and shock. However, 11-hydroxylase and 17-alpha-hydroxylase-deficient patients may be hypokalemic, and Electrolyte imbalance is caused by adrenal insufficiency, while hypoglycemia and hypotension results from cortisol deficiency (Haldeman-Englert n. pag.; Wilson n. pag.). Treatment In managing patients with CAH, a comprehensive approach on treatment is needed, since the condition does not only affect the physical, but the emotional and psychological aspects of the patient as well. It should, thus, involve medical therapy, surgical intervention and lifestyle modifications. Medical intervention Primarily, the role of medical intervention is to replace glucocorticoids and mineralocorticoids, as well as to decrease the serum levels of virilizing precursor hormones. However, certain medications are necessary to avoid fatal consequences resulting from the symptoms of adrenal insufficiency (Wilson n. pag.). 1.) Corticoids Physiologically, glucocorticoids and mineralocorticoids released by adrenal glands in response to increased levels of adrenocorticotropin hormone (ACTH) are important in regulating normal glucose and electrolyte levels, respectively. In CAH therapy, glucocorticoids are given to suppress the perpetually elevated ACTH levels and adrenal androgen production, while mineralocorticoid therapy reduces angiotensin II levels that regulate blood pressure. All healthcare providers or caretakers of CAH patients should always have an injectable glucocorticoid at hand in case of rapid decline. These medications are safe, since they are normal products of the body, they do not have contraindications, and they only have minimal drug-drug interactions (Wilson n. pag.). Normally, increased levels of cortisol are apparent among individuals who experience stress or illness. Ho wever, as mentioned above, such response is absent among CAH patients due to lack of enzymes needed to produce cortisol. Thus, among CAH individuals, in cases of stress or illnesses, stress dosages of hydrocortisone (50-100 mg/m2 or 1-2